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| How do I know which of my transplant patients are at risk for CMV? |
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| Cytomegalovirus (CMV) is the most common and problematic viral infection in solid organ transplant recipients (i.e. transplant recipients). Current immunosuppressive therapies used to prevent the rejection of a transplanted organ have detrimental effects upon the T-lymphocytes and cell-mediated immune responses in transplant recipients. These patients have an increased susceptibility to viral infections post-transplant. Approximately half of these patients show signs of active CMV infection (ie. viral replication) after completion of antiviral prophylaxis. Consequently, CMV-associated morbidity and mortality in transplant recipients are very high. Infection can result not only in organ-specific conditions affecting the brain, lungs, and liver, but also in opportunistic infections, increased allograft rejection, and patient death. These CMV-related complications add an estimated 49% to the cost of transplant care. For more specific information about CMV, please view the QuantiFERON-CMV Brochure. |
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The immune status of a transplant recipient can influence the (re)activation of CMV in transplant recipients. |
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A specific cytokine marker for cellular immune responses, interferon-gamma (IFN-γ) plays a key role. |
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IFN-γ is secreted from CMV-specific T-cells in response to antigens associated with CMV infection. |
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IFN-γ levels may indicate a patient’s overall level of cell-mediated immunity. |
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| To learn more about CMV in transplant recipients and how QuantiFERON-CMV can monitor a person's risk of CMV disease, view the CMV Physician Brochure. |
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Immunity to CMV during post-transplantation prophylaxis: A theoretical model of QuantiFERON-CMV responses.
View video. |
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Click to have your questions about QF-CMV answered |
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Disclaimer
QuantiFERON-CMV is CE Marked for commercial use in Europe. QuantiFERON-CMV is not US FDA-approved and is available for investigational use only in the US. QF-CMV is not a test for CMV infection. |
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Contact
Cellestis Limited
World Headquarters
Email: info@cellestis.com
Tel: +61 3 8527 3500 |
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